NAD(P)+—protein-arginin ADP-riboziltransferaza
| NAD(P)+—protein-arginin ADP-riboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.31 | ||||||||
| CAS broj | 81457-93-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
NAD(P)+—protein-arginin ADP-riboziltransferaza (EC 2.4.2.31, ADP-riboziltransferaza, mono(ADP-ribozil)transferaza, NAD+:L-arginin ADP-D-riboziltransferaza, NAD(P)+-arginin ADP-riboziltransferaza, NAD(P)+:L-arginin ADP-D-riboziltransferaza, mono-ADP-riboziltransferaza, ART, ART1, ART2, ART3, ART4, ART5, ART6, ART7, NAD(P)+---protein-arginin ADP-riboziltransferaza, NAD(P)+:protein-L-arginin ADP-D-riboziltransferaza) je enzim sa sistematskim imenom NAD+:protein-L-arginin ADP-D-riboziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- NAD+ + protein L-arginin nikotinamid + Nomega-(ADP-D-ribozil)-protein-L-arginin
Protein mono-ADP-ribozilation se reverzibilno posttranslaciono modifikuje, čime se utiče na regulaciju ćelijskih aktivnosti.
- ↑ Moss, J., Stanley, S.J. and Oppenheimer, N.J. (1979). „Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes”. J. Biol. Chem. 254: 8891-8894. PMID 225315.
- ↑ Moss, J., Stanley, S.J. and Watkins, P.A. (1980). „Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes”. J. Biol. Chem. 255: 5838-5840. PMID 6247348.
- ↑ Ueda, K. and Hayaishi, O. (1985). „ADP-ribosylation”. Annu. Rev. Biochem. 54: 73-100. PMID 3927821.
- ↑ Corda, D. and Di Girolamo, M. (2003). „Functional aspects of protein mono-ADP-ribosylation”. EMBO J. 22: 1953-1958. PMID 12727863.
- ↑ Paone, G., Stevens, L.A., Levine, R.L., Bourgeois, C., Steagall, W.K., Gochuico, B.R. and Moss, J. (2006). „ADP-ribosyltransferase-specific modification of human neutrophil peptide-1”. J. Biol. Chem. 281: 17054-17060. PMID 16627471.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
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