Alminoprofen

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Alminoprofen
(IUPAC) ime
2-[4-(2-methylprop-2-enylamino)phenyl]propanoic acid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 39718-89-3
ATC kod M01AE16
PubChem[1][2] 2097
ChemSpider[3] 2013
UNII 0255AHR9GJ YesY
KEGG[4] D01513 YesY
Hemijski podaci
Formula C13H17NO2 
Mol. masa 219.27958 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Alminoprofen ke nesteroidni antiinflamatorni lek iz klase fenilpropionskih kiselina.[5][6] Njegove antiinflamatorne osobine se razlikuju od klasičnih NSAID lekova.

Mehanizam dejstva[uredi - уреди | uredi izvor]

In vitro ispitivanja i in vivo modeli su pokazali da su inflamatorna svojstva alminoprofena posledica njegovog delovanja na fosfolipazu A2 (PLA2) i cikloksigenazu (COX-2).[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. B. Dumaitre et al. (1979). "Synthesis, pharmacology and toxicity data,". Eur. J. Med. Chem. 14: 207. 
  6. A. Premel-Cabic et al. (1980). "Pharmacokinetic study". Eur. J. Clin. Pharmacol. 18: 419. 
  7. Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL, Streichenberger G. (1999). "Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway". Biochem Pharmacol 4: 433–43. 


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