Proglumetacin
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(IUPAC) ime | |||
---|---|---|---|
34-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 57132-53-3 59209-40-4 (maleat) | ||
ATC kod | M01AB14 | ||
PubChem[1][2] | 4921 | ||
ChemSpider[3] | 4752 | ||
Hemijski podaci | |||
Formula | C46H58ClN5O8 | ||
Mol. masa | 844.43442 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Sinonimi | 3-[4-[2-[2-[1-(4-hlorobenzoil)-5-metoksi-2-metilindol-3-il]acetil]oksietil]piperazin-1-il]propil 4-(benzoilamino)-5-(dipropilamino)-5-oksopentanoat | ||
Farmakokinetički podaci | |||
Metabolizam | Hepatički | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Proglumetacin (Afloksan, Protakson i Proksil) je ne-steroidni antiinflamatorni lek. On se metabolizuje u telu do indometacina i proglumida,[4] leka sa antisekretornim dejstvom koji pomaže u sprečavanju povreda sluzokože želuca. Proglumetacin se obično koristi u obliku maleatnih soli.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). „Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog”. Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.