Moeksipril

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Moeksipril
(IUPAC) ime
(3S)-2-[(2S)-2- {[(2S)-1-etoksi-1-okso-4-fenilbutan-2-il]amino}propanoil]-6,7-dimetoksi-1,2,3,4-tetrahidroizohinolin-3-karboksilna kiselina
Klinički podaci
Robne marke Univasc
AHFS/Drugs.com Monografija
MedlinePlus a695018
Identifikatori
CAS broj 103775-10-6
ATC kod C09AA13
PubChem[1][2] 91270
DrugBank DB00691
ChemSpider[3] 82418
UNII WT87C52TJZ YesY
KEGG[4] D08225 YesY
ChEMBL[5] CHEMBL1165 YesY
Hemijski podaci
Formula C27H34N2O7 
Mol. masa 498,568 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća D(US)
Pravni status POM (UK) -only (SAD)
Način primene Oralno

Moeksipril hidrohlorid je potentan oralno aktivan nesulfhidrilni inhibitor angiotenzin konvertujućeg enzima (ACE),[6] koji se koristi za tretiranje hipertenzije i zatajenja srca. Moeksipril se može administrirati pojedinačno ili zajedno sa drugim antihipertenzivima ili diureticima.[7] On deluje putem inhibicije konverzije angiotenzina I u angiotenzin II.[8] Moeksipril je dostupan pod imenom Univasc.[8][9]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Hochadel, Maryanne, ur. (2006). The AARP Guide to Pills. Sterling Publishing Company. str. 640. ISBN 978-1-4027-1740-6. http://books.google.ca/books?id=WvcaI-7TuaMC&pg=RA1-PA64. pristupljeno 9. 10. 2009.. 
  7. Belal, F.F, K.M. Metwaly, and S.M. Amer. "Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids." Portugaliae Electrochimica Acta. 27.4 (2009): 463-475.
  8. 8,0 8,1 Rodgers, Katie, Michael C Vinson, and Marvin W Davis. "Breakthroughs: New drug approvals of 1995 -- part 1." Advanstar Communications, Inc. 140.3 (1996): 84.
  9. Dart, Richard C. (2004). Medical toxicology. Lippincott Williams & Wilkins. str. 647. ISBN 978-0-7817-2845-4. http://books.google.ca/books?id=BfdighlyGiwC&pg=PA647. pristupljeno 9. 10. 2009.. 

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Spoljašnje veze[uredi - уреди | uredi izvor]

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