Cilazapril

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Cilazapril
Kekulé, stereo, skeletal formula of cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox)
IUPAC ime
Identifikacija
CAS registarski broj 88768-40-5 YesY
PubChem[1][2] 56330
40467985 (1R,9S)-(2S)-butilamino izomer
ChemSpider[3] 50831 YesY
UNII 8Q9454114Q YesY
DrugBank DB01340
KEGG[4] D07699
ChEMBL[5] CHEMBL515606 YesY
ATC code C09AA08
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C22H31N3O5
Molarna masa 417.5 g mol−1
log P 2,212
pKa 2,285
Baznost (pKb) 11,712
Farmakologija
Načini upotrebe Oralno
Legalni status

POM(UK)

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Cilazapril je inhibitor angiotenzin konvertujućeg enzima (ACE inhibitor) koji se koristi za tretiranje hipertenzije i zatajenja srca.[6][7] Neka od prodajnih imena ovog leka su: Inhibace, Vascace i Dynorm.[8][9]

Osobine[uredi - уреди | uredi izvor]

Osobina Vrednost
Broj akceptora vodonika 7
Broj donora vodonika 2
Broj rotacionih veza 9
Particioni koeficijent[10] (ALogP) -0,7
Rastvorljivost[11] (logS, log(mol/L)) -3,5
Polarna površina[12] (PSA, Å2) 99,2

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 Suppl 1: 18–24. PMID 1712267. 
  7. Jasek, W, ur. (2007) (German). Austria-Codex (2007/2008 izd.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4. 
  8. Drugs.com: Cilazapril
  9. Cilazapril monograph. Lexi-Comp Online, Lexi-Drugs Online, Lexi-Comp Inc. Hudson, OH. Available at: [1]. Accessed October 5, 2008.
  10. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods". J. Phys. Chem. A 102: 3762–3772. doi:10.1021/jp980230o. 
  11. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488–1493. PMID 11749573. doi:10.1021/ci000392t.  edit
  12. Ertl P., Rohde B., Selzer P. (2000). "Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties". J. Med. Chem. 43: 3714–3717. PMID 11020286. doi:10.1021/jm000942e.  edit

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]

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