2,3-Bisfosfoglicerinska kiselina

2,3-Bisfosfoglicerinska kiselina
	2,3-Bisfosfoglicerat
Drugi nazivi	2,3-Difosfoglicerna kiselina; 2,3-Difosfoglicerat; 2,3-Bisfosfoglicerat
Identifikacija
Abrevijacija	2,3-BPG; 2,3-DPG; 23BPG
CAS registarski broj	138-81-8
PubChem	61
ChemSpider	161681 , 60 (Racemat)
ChEBI	17720
Jmol-3D slike	Slika 1
SMILES
	O=P(O)(OC(C(=O)O)COP(=O)(O)O)O
InChI
	InChI=1S/C3H8O10P2/c4-3(5)2(13-15(9,10)11)1-12-14(6,7)8/h2H,1H2,(H,4,5)(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1 ; Kod: XOHUEYCVLUUEJJ-UWTATZPHSA-N
Svojstva
Molekulska formula	C3H8O10P2
Molarna masa	266.04 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

2,3-Bisfosfoglicerinska kiselina (2,3-Bisfosfoglicerat, 2,3-BPG, 2,3-difosfoglicerat, 2,3-DPG) je trougljenični izomer glikolitičkog intermediera 1,3-bisfosfoglicerinska kiselina (1,3-BPG). 2,3-BPG je prisutna u ljudskim crvenim krvnim zrncima (RBC; eritrocitima) na nivou od aproksimativno 5 mmol/L. Ona se vezuje sa velikim afinitetom za dezoksigenisani hemoglobin (e.g. kad su crvena krvna zrnca blizo plučnog tkiva).

Funkcija 2,3-bisfosfoglicerinske kiseline je otkrivena 1967.^[4]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Benesch, R.; Benesch, R.E. (1967). „The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin”. Biochem Biophys Res Commun 26 (2): 162–7. DOI:10.1016/0006-291X(67)90228-8. PMID 6030262.

Literatura[uredi | uredi kod]

Berg, J.M., Tymockzko, J.L. and Stryer L. Biochemistry (5th ed). W.H. Freeman and Co, New York, 1995. ISBN 0-7167-4684-0.
Online medical dictionary Arhivirano 2006-09-10 na Wayback Machine-u
David L. Nelson, Michael M. Cox (2005). Principles of Biochemistry (4th izd.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
Muller-esterl,W. "Biochemistry: "Fundamentals Of Medicine And The Science Of Life (2nd ed.)". Reverté, 2008. ISBN 84-291-7393-5.
Rodak. "Hematology. Clinical principles and applications (2nd ed.)" Elsevier Science, Philadelphia, 2003. ISBN 950-06-1876-1.
González-Cinca N, Pérez de la Ossa P, Carreras J, Climent F."Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo". Unitat de Bioquímica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain, 2004.
Nielsen AL, Andersen EM, Jørgensen LG, Jensen HA. "Oxygen and 2,3 biphosphoglycerate (2,3-BPG) during haemodialysis". Department of Nephrology, Hvidovre University Hospital, Denmark, 1998.
"Anales de la Real Academia Nacional de Medicina (cuaderno cuarto)". ISSN: 0034-0634

Spoljašnje veze[uredi | uredi kod]

Portal Hemija

A live model of the effect of changing 2,3 BPG on the oxyhaemoglobin saturation curve Arhivirano 2010-08-31 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[Benesch1967-4] Benesch, R.; Benesch, R.E. (1967). „The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin”. Biochem Biophys Res Commun 26 (2): 162–7. DOI:10.1016/0006-291X(67)90228-8. PMID 6030262.

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2,3-Bisfosfoglicerinska kiselina

Reference[uredi | uredi kod]

Literatura[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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