Pilokarpin

Izvor: Wikipedia
Pilokarpin
(IUPAC) ime
(3S,4R)- 3-etil- 4-((1-metil- 1H-imidazol- 5-il) metil)dihidrofuran- 2(3H)-on
Klinički podaci
Robne marke Salagen
AHFS/Drugs.com Monografija
MedlinePlus a608039
Identifikatori
CAS broj 92-13-7
54-71-7 (hidrohlorid)
ATC kod N07AX01 S01EB01
PubChem[1][2] 5910
DrugBank APRD00382
ChemSpider[3] 5699
UNII 01MI4Q9DI3 YesY
KEGG[4] D00525 YesY
ChEBI CHEBI:8207 YesY
ChEMBL[5] CHEMBL550 YesY
Hemijski podaci
Formula C11H16N2O2 
Mol. masa 208.257 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 0,76 sata (5 mg), 1,35 sata (10 mg)[6]
Izlučivanje urin
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status -only (SAD)
Način primene kapi, oralno

Pilokarpin je parasimpatomimetički alkaloid koji se dobija iz lišća tropskih američkih žbunova iz roda Pilocarpus. On je neselektivni agonist muskarinskog receptora[7] u parasimpatičkom nervnom sistemu, sa terapeutskim dejstvom na muskarinski acetilholinski receptor M3. On se primenjuje topički,[8] npr., u lečenju glaukoma i kserostomije.

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:<48::AID-YEA2>3.0.CO;2-H 10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Mervyn Gornitsky, George Shenouda, Khalil Sultanem, Howard Katz, Michael Hier, Martin Black, Ana M Velly (2004). "Double-blind randomized, placebo-controlled study of pilocarpine to salvage salivary gland function during radiotherapy of patients with head and neck cancer". Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 98 (1): 45-52. 
  7. Spalding et al. 2002.
  8. Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 144.

Literatura[uredi - уреди]

  • The Italian Journal of Neurological Sciences Volume 16, Numbers 1-2, 33-37, DOI: 10.1007/BF02229072
  • Pathophysiology of Status Epilepticus Induced by Pilocarpine, central nervous system agents in medical chemistry, 2007, vol. 7, no. 1

Spoljašnje veze[uredi - уреди]


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