AR-R17779

AR-R17779
	(2S)-2′H-spiro[4-azabiciklo[2.2.2]oktan-2,5'-[1,3]oksazolidin]-2'-on
Identifikacija
CAS registarski broj	178419-47-1
PubChem	5310971
ChemSpider	4470515
ChEBI	CHEBI:420311
ChEMBL	CHEMBL193016
Jmol-3D slike	Slika 1
SMILES
	O=C3O[C@]1(CN2CCC1CC2)CN3
InChI
	InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1 ; Kod: TYAGAVRSOFABFO-VIFPVBQEBZ InChI=1/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
Svojstva
Molekulska formula	C9H14N2O2
Molarna masa	182.22 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

AR-R17779 je lek koji deluje kao potentan i selektivan pun agonist za α7 podtip neurskih nikotinskih acetilholinskih receptora.^[5]^[6] On ispoljava nootropne efekte u životinjskim studijama,^[7]^[8] mada ta dejstva ne zamenjuju dejstva nikotina.^[9] On je nedavno izučavan kao potentan nov tretman za artritis.^[10]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Mullen, G.; Napier, A.; Balestra, M.; Decory, T.; Hale, G.; Macor, J.; Mack, R.; Loch J, J. i dr.. (2000). „(-)-Spiro1-azabicyclo2.2.2octane-3,5'-oxazolidin-2'-one, a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor”. Journal of Medicinal Chemistry 43 (22): 4045–4050. DOI:10.1021/jm000249r. PMID 11063601.
↑ Macor, J. .; Mullen, G. .; Verhoest, P. .; Sampognaro, A. .; Shepardson, B. .; Mack, R. . (2004). „A chiral synthesis of (-)-spiro1-azabicyclo2.2.2octane-3,5'- oxazolidin-2'-one: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist”. The Journal of Organic Chemistry 69 (19): 6493–6495. DOI:10.1021/jo049404q. PMID 15357617.
↑ Levin, E. D.; Bettegowda, C.; Blosser, J.; Gordon, J. (1999). „AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats”. Behavioural Pharmacology 10 (6–7): 675–680. DOI:10.1097/00008877-199911000-00014. PMID 10780509.
↑ Van Kampen, M.; Selbach, K.; Schneider, R.; Schiegel, E.; Boess, F.; Schreiber, R. (2004). „AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors”. Psychopharmacology 172 (4): 375–383. DOI:10.1007/s00213-003-1668-7. PMID 14727003.
↑ Grottick, A. J.; Trube, G.; Corrigall, W. A.; Huwyler, J.; Malherbe, P.; Wyler, R.; Higgins, G. A. (2000). „Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine”. The Journal of Pharmacology and Experimental Therapeutics 294 (3): 1112–1119. PMID 10945867.
↑ Van Maanen, M.; Lebre, M.; Van Der Poll, T.; Larosa, G.; Elbaum, D.; Vervoordeldonk, M.; Tak, P. (2009). „Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice”. Arthritis and rheumatism 60 (1): 114–122. DOI:10.1002/art.24177. PMID 19116908.

Spoljašnje veze[uredi | uredi kod]

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Mullen, G.; Napier, A.; Balestra, M.; Decory, T.; Hale, G.; Macor, J.; Mack, R.; Loch J, J. i dr.. (2000). „(-)-Spiro1-azabicyclo2.2.2octane-3,5'-oxazolidin-2'-one, a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor”. Journal of Medicinal Chemistry 43 (22): 4045–4050. DOI:10.1021/jm000249r. PMID 11063601.

[6] Macor, J. .; Mullen, G. .; Verhoest, P. .; Sampognaro, A. .; Shepardson, B. .; Mack, R. . (2004). „A chiral synthesis of (-)-spiro1-azabicyclo2.2.2octane-3,5'- oxazolidin-2'-one: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist”. The Journal of Organic Chemistry 69 (19): 6493–6495. DOI:10.1021/jo049404q. PMID 15357617.

[7] Levin, E. D.; Bettegowda, C.; Blosser, J.; Gordon, J. (1999). „AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats”. Behavioural Pharmacology 10 (6–7): 675–680. DOI:10.1097/00008877-199911000-00014. PMID 10780509.

[8] Van Kampen, M.; Selbach, K.; Schneider, R.; Schiegel, E.; Boess, F.; Schreiber, R. (2004). „AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors”. Psychopharmacology 172 (4): 375–383. DOI:10.1007/s00213-003-1668-7. PMID 14727003.

[9] Grottick, A. J.; Trube, G.; Corrigall, W. A.; Huwyler, J.; Malherbe, P.; Wyler, R.; Higgins, G. A. (2000). „Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine”. The Journal of Pharmacology and Experimental Therapeutics 294 (3): 1112–1119. PMID 10945867.

[10] Van Maanen, M.; Lebre, M.; Van Der Poll, T.; Larosa, G.; Elbaum, D.; Vervoordeldonk, M.; Tak, P. (2009). „Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice”. Arthritis and rheumatism 60 (1): 114–122. DOI:10.1002/art.24177. PMID 19116908.

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AR-R17779

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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