PHA-543,613

Izvor: Wikipedia
PHA-543,613
(IUPAC) ime
N-[(3R)-1-azabiciklo[2.2.2]okt-3-il]furo[2,3-c]piridin-5-karboksamid
Klinički podaci
Identifikatori
CAS broj 478149-53-0
ATC kod nije dodeljen
PubChem[1][2] 11493927
ChEMBL[3] CHEMBL214268
Hemijski podaci
Formula C15H17N3O2 
Mol. masa 271,314
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

PHA-543,613 je lek koji deluje kao potentan i selektivan agonist za α7 podtip neuronskih nikotinskih acetilholinskih receptora. On ima visok nivo moždane penetracije i dobru oralnu biodostupnost. Ovaj ligand je u razvoju za moguću primenu u tretmanu kognitivnih deficita kod obolelih od šizofrenije.[4]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. Wishka, D.; Walker, D.; Yates, K.; Reitz, S.; Jia, S.; Myers, J.; Olson, K.; Jacobsen, E. et al. (2006). "Discovery of N-(3R)-1-azabicyclo2.2.2oct-3-ylfuro2,3-cpyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship". Journal of Medicinal Chemistry 49 (14): 4425–4436. doi:10.1021/jm0602413. PMID 16821801. 

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