1-Oktakozanol

1-Oktakozanol
	Octacosan-1-ol
Drugi nazivi	n-Oktakozanol; Oktakozil alkohol; Oktanozol; Montanil alkohol; Klujitil alkohol
Identifikacija
CAS registarski broj	557-61-9
PubChem	68406
ChemSpider	61689
UNII	81I2215OVK
KEGG	C08387
MeSH	1-octacosanol
ChEBI	28243
Jmol-3D slike	Slika 1
SMILES
	OCCCCCCCCCCCCCCCCCCCCCCCCCCCC
InChI
	InChI=1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3 ; Kod: CNNRPFQICPFDPO-UHFFFAOYSA-N InChI=1/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3; Kod: CNNRPFQICPFDPO-UHFFFAOYAC
Svojstva
Molekulska formula	C28H58O
Molarna masa	410.76 g mol−1
Tačka topljenja	83 °C, 356 K, 181 °F
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1-Oktakozanol (n-oktakozanol, oktakozil alkohol, klujitil alkohol, montanil alkohol) alifatični alkohol pravog lanca sa 28 ugljenika. On je primarni masni alkohol koji je prisutan u biljnom vosku.^[5] Oktakozanol se takođe javlja u pšeničnim klicama.^[6]

Hemija[uredi | uredi kod]

Oktakozanol nije rastvoran u vodi, ali je rastvoran u alkanima niske molekulske težine i u hloroformu.

Biološka dejstva[uredi | uredi kod]

Oktakozanol je glavni sastojak polikozanola. On ima više farmakoloških dejstava,^[7] i potencijalno može da bude koristan u tretmanu Parkinsonove bolesti.^[8]^[9]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp139-165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3
↑ „Octacosanol”. Natural Products (Professional). drugs.com. Arhivirano iz originala na datum 2009-06-03. Pristupljeno 09-July-2009. »isolated from wheat germ oil or other plants«
↑ Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). „Octacosanol in human health”. Nutrition 19 (2): 192–5. DOI:10.1016/S0899-9007(02)00869-9. PMID 12591561.
↑ Snider, SR (1984). „Octacosanol in parkinsonism”. Annals of neurology 16 (6): 723. DOI:10.1002/ana.410160615. PMID 6395790.
↑ Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). „Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling”. Acta pharmacologica Sinica 31 (7): 765–74. DOI:10.1038/aps.2010.69. PMID 20581854.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[Baker-5] EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp139-165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3

[6] „Octacosanol”. Natural Products (Professional). drugs.com. Arhivirano iz originala na datum 2009-06-03. Pristupljeno 09-July-2009. »isolated from wheat germ oil or other plants«

[7] Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). „Octacosanol in human health”. Nutrition 19 (2): 192–5. DOI:10.1016/S0899-9007(02)00869-9. PMID 12591561.

[8] Snider, SR (1984). „Octacosanol in parkinsonism”. Annals of neurology 16 (6): 723. DOI:10.1002/ana.410160615. PMID 6395790.

[9] Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). „Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling”. Acta pharmacologica Sinica 31 (7): 765–74. DOI:10.1038/aps.2010.69. PMID 20581854.

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p r u Alkoholi
(0°)	Metanol
Primarni alkoholi (1°)	Etanol • Propan-1-ol • Butanol/Izobutanol • 1-Pentanol • 1-Heksanol • 1-Heptanol Masni alkohol: 1-Oktanol (C₈) • 1-Nonanol (C₉) • 1-Dekanol (C₁₀) • Undekanol (C₁₁) • Dodekanol (C₁₂) • 1-Tetradekanol (C₁₄) • Cetil alkohol (C₁₆) • Stearil alkohol (C₁₈) • Arahidil alkohol (C₂₀) • Dokozanol (C₂₂) • Tetrakozanol (C₂₄) • Heksakozanol (C₂₆) • Oktanozol (C₂₈) • Triakontanol (C₃₀) Polikozanol
Sekondarni alkoholi (2°)	Izopropil alkohol • 2-Butanol • 2-Heksanol • Cikloheksanol
Tercijarni alkoholi (3°)	tert-Butanol • 2-Metil-2-butanol
Biohemijske familije: Ugljeni hidrati (Glikozidi,Alkoholi) • Lipidi (Steroidi,Fosfolipidi,Glikolipidi,Masne kiseline,Tetrapiroli) • Proteini (Aminokiseline,Peptidi,Glikoproteini) • Nukleobaze/Nukleinske kiseline

1-Oktakozanol

Hemija[uredi | uredi kod]

Biološka dejstva[uredi | uredi kod]

Reference[uredi | uredi kod]

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