Penicilamin

Penicilamin
(IUPAC) ime
	2-amino-3-metil-3-fulfanilbutanoinska kiselina
Klinički podaci
Robne marke	Artamine, Cuprenil, Cuprimine, Cupripen
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	52-67-5
ATC kod	M01CC01
DrugBank	DB00859
KEGG	C07418
ChEMBL	CHEMBL50868
Hemijski podaci
Formula	C5H11NO2S
Mol. masa	149.211
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8); Key: VVNCNSJFMMFHPL-UHFFFAOYSA-N
Fizički podaci
Tačka topljenja	198.5 °C (389 °F)
Farmakokinetički podaci
Poluvreme eliminacije	1 sad
Izlučivanje	Renalno, uglavno u obliku disulfida.
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno

Penicilamin (3-merkapto-D-valin) je najkarakterističniji degradacioni produkt penicilinskih antibiotika. On se koristi kao antireumatski i helacini agens za Vilsonovu bolest.^[3]^[4]^[5]^[6]^[7]^[8]^[9]

Reference

↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ WALSHE JM: Penicillamine, a new oral therapy for Wilson's disease. Am J Med. 1956 Oct;21(4):487-95. PMID 13362281
↑ Walshe JM: The story of penicillamine: a difficult birth. Mov Disord. 2003 Aug;18(8):853-9. PMID 12889074
↑ Gong Y, Frederiksen SL, Gluud C: D-penicillamine for primary biliary cirrhosis. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004789. PMID 15495127
↑ Suarez-Almazor ME, Spooner C, Belseck E: Penicillamine for rheumatoid arthritis. Cochrane Database Syst Rev. 2000;(2):CD001460. PMID 10796440
↑ Munro R, Capell HA: Penicillamine. Br J Rheumatol. 1997 Jan;36(1):104-9. PMID 9117147
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Penicillamine

[1] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[3] WALSHE JM: Penicillamine, a new oral therapy for Wilson's disease. Am J Med. 1956 Oct;21(4):487-95. PMID 13362281

[4] Walshe JM: The story of penicillamine: a difficult birth. Mov Disord. 2003 Aug;18(8):853-9. PMID 12889074

[5] Gong Y, Frederiksen SL, Gluud C: D-penicillamine for primary biliary cirrhosis. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004789. PMID 15495127

[6] Suarez-Almazor ME, Spooner C, Belseck E: Penicillamine for rheumatoid arthritis. Cochrane Database Syst Rev. 2000;(2):CD001460. PMID 10796440

[7] Munro R, Capell HA: Penicillamine. Br J Rheumatol. 1997 Jan;36(1):104-9. PMID 9117147

[8] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.

[9] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.

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