Dimetilglicin

Izvor: Wikipedia
Dimetilglicin
Skeletal formula of dimethylglycine
IUPAC ime
Drugi nazivi N,N-Dimetilglicin
Identifikacija
CAS registarski broj 1118-68-9 YesY
PubChem[2][3] 673
ChemSpider[4] 653 YesY
EINECS broj 214-267-8
DrugBank DB02083
KEGG[5] C01026
MeSH dimethylglycine
ChEBI 17724
RTECS registarski broj toksičnosti MB9865000
Bajlštajn 1700261
Gmelin Referenca 82215
3DMet B00224
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C4H9NO2
Molarna masa 103.12 g mol−1
Agregatno stanje Beli kristali
Miris Bez mirisa
Tačka topljenja

178-182 °C, 451-455 K, 352-360 °F

Opasnost
LD50 >650 mg kg−1 (oralno, pacov)
Srodna jedinjenja
Srodna alkanoinske kiseline
Srodna jedinjenja Dimetilacetamid

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Dimetilglicin (DMG) je derivat aminokiseline glicina sa strukturnom formulom (CH3)2NCH2COOH. On je prisutan u pasulju i jetri. On se može formirati iz trimetilglicina nakon gubitka jedne od njegovih metil grupa. On je takođe nusproizvod metabolizma holina.

Upotrebe[uredi - уреди]

Dimetilglicin je predložen za moguću primenu kao sredstvo za poboljšanje atletske performance, imunostimulant, i za tretman autizma, epilepsije, i mitohondrijalne bolesti.[6][7] Objavljene studije su pokazale da nema znatne razlike imeđu tretmana autiyma DMG-om i placebom.[8][9]

Reference[uredi - уреди]

  1. "dimethylglycine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=673#x291. pristupljeno 24. 4. 2012.. 
  2. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  3. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  4. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  5. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  6. "Dimethylglycine". About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009.. http://www.mskcc.org/mskcc/html/69204.cfm. 
  7. Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). "Treatment for mitochondrial disorders". Cochrane Database of Systematic Reviews (Online) (1): CD004426. doi:10.1002/14651858.CD004426.pub2. PMID 16437486. 
  8. Bolman WM, Richmond JA (June 1999). "A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder". Journal of Autism and Developmental Disorders 29 (3): 191–4. PMID 10425581. 
  9. Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). "Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder". Journal of Child Neurology 16 (3): 169–73. PMID 11305684. 

Spoljašnje veze[uredi - уреди]