Oleamid
| Oleamid | |||
|---|---|---|---|
| |||
| IUPAC ime |
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| Drugi nazivi | Oleilamid 9-Oktadecenamid (Z)-9-Oktadecenamid 9,10-Oktadecenoamid Amid oleinske kiseline Cis-9,10-oktadecenoamid | ||
| Identifikacija | |||
| CAS registarski broj | 301-02-0 
| ||
| PubChem[1][2] | 5283387 | ||
| ChemSpider[3] | 4446508
| ||
| UNII | 7L25QK8BWO
| ||
| EINECS broj | |||
| ChEBI | 116314 | ||
| ChEMBL[4] | CHEMBL15927
| ||
| IUPHAR ligand | 284 | ||
| Jmol-3D slike | Slika 1 | ||
| |||
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| Svojstva | |||
| Molekulska formula | C18H35NO | ||
| Molarna masa | 281.48 g mol−1 | ||
| Agregatno stanje | Kremasta čvrsta materija[5] | ||
| Gustina | 0,879 g/cm3 | ||
| Tačka topljenja |
102-104 °C[5] | ||
| Tačka ključanja |
>200 °C[5] | ||
| Rastvorljivost u vodi | Nerastvoran je[5] | ||
| Opasnost | |||
| NFPA 704 |
 0
1
0
| ||
| Tačka paljenja | >200 °C[5] | ||
|
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
Oleamid je amid oleinske kiseline. On je endogena supstanca, koja se prirodno javlja u telu životinja. On se akumulira u cerebrospinalnom fluidu tokom deprivacije sna i indukuje san kod životinja.[6] On je izučavan kao potencijalni medicinski tretman za poremećaje raspoloženja i sna, i kanabinoidima regulisane depresije.[7][8]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 5,0 5,1 5,2 5,3 5,4 Oleamide at chemicalland21.com
- ↑ Salvador Huitron-Resendiz, Lhys Gombart, Benjamin F. Cravatt, and Steven J. Henriksen (2001). „Effect of Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity in Rats”. Experimental Neurology 172 (1): 235–243. DOI:10.1006/exnr.2001.7792. PMID 11681856.
- ↑ „Methods of treating anxiety and mood disorders with oleamide - US Patent 6359010”. Arhivirano iz originala na datum 2011-06-12. Pristupljeno 2014-04-11.
- ↑ Raphael Mechoulam, Ester Fride, Lumír Ondřej Hanuš, Tzviel Sheskin, Tiziana Bisogno, Vincenzo Di Marzo, Michael Bayewitch and Zvi Vogel (1997). „Anandamide may mediate sleep induction”. Nature 389 (6646): 25–26. DOI:10.1038/37891. PMID 9288961.
