CCL16

Izvor: Wikipedia
chemokine (C-C motif) ligand 16
Identifikatori
Simbol CCL16
Alt. simboli SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1
Entrez 6360
HUGO 10614
OMIM 601394
RefSeq NM_004590
UniProt O15467
Drugi podaci
Lokus Hromozom 17 q11.2

CCL16, hemokin (C-C motif) ligand 16, je mali citokin iz CC hemokin familije koji je poznat pod nekoliko pseudonima, uključujući LEC (eng. Liver-expressed chemokine - hemokin izražen u jetri), i monotaktin-1 (MTN-1). Ovaj hemokin je izražen u jetri, timusu, i slezini. On je hemoatraktant za monocite i limfocite.[1] CCL16 ćelijska ekspresija se može jako indukovati u monocitima sa IL-10, IFN-γ i bakterijskim lipopolisaharidima. Njegov gen je lociran na hromozomu 17 kod ljudi, u klasteru sa drugim CC hemokinima.[2] CCL16 dejstvuje na ćelije putem interakcija sa hemokinskim receptorima na ćelijskoj površini kao što su CCR1, CCR2, CCR5 i CCR8.[3][4][5]

Reference[uredi - уреди]

  1. Youn et al. (1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.". Biochem. Biophys. Res. Commun. 247: 217–222. 
  2. Nomiyama et al. (1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.". J. Interferon Cytokine Res. 19: 227–234. 
  3. Nomiyama et al. (2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes.". Int Immunol 13 (8): 1021–9. 
  4. Howard et al. (2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.". Blood 96 (3): 840–5. 
  5. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 

Spoljašnje veze[uredi - уреди]