CCL27

Izvor: Wikipedia
Hemokin (C-C motiv) ligand 27
Identifikatori
Simbol CCL27
Alt. simboli SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Entrez 10850
HUGO 10626
OMIM 604833
RefSeq NM_006664
UniProt Q9Y4X3
Drugi podaci
Lokus Hromozom 9 q13

CCL27, hemokin (C-C motiv) ligand 27, je mali citokin iz CC hemokin familije koji je takođe poznat pod imenima IL-11 R-alfa-lokus hemokin (ILC), skinkin, ESkin i kožni T-ćelijski atraktivni hemokin (CTACK). On je asociran sa navođenjem memorijskih T limfocita ka koži, i on učestvuje u T ćelijama posredovanoj inflamaciji kože.[1][2] CCL27 je izražen u brojnim tkivima, među kojima su gonade, timus, posteljica i koža. On ispoljava svoje hemotaksne efekte vezivanjem za hemokinski receptor CCR10.[3] CCL27 gen je lociran na ljudskom hromozomu 9.[4][5]

Reference[uredi - уреди]

  1. Morales et al. (1999). "CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells". Proc. Natl. Acad. Sci. U.S.A. 96: 14470–14475. 
  2. Homey et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Med 8: 157–165. 
  3. Homey et al. (2000). "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164: 3465–3470. 
  4. Ishikawa-Mochizuki et al. (1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Lett 460: 544–548. 
  5. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 

Spoljašnje veze[uredi - уреди]