Vitamin-K-epoksid reduktaza (varfarin-sensitivna)
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| Vitamin-K-epoksid reduktaza (varfarin-sensitivna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.4.1 | ||||||||
| CAS broj | 55963-40-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Vitamin-K-epoksid reduktaza (varfarin-sensitivna) (EC 1.1.4.1, vitamin-K-epoksidna reduktaza (varfarin-sensitivna)) je enzim sa sistematskim imenom 2-metil-3-fitil-1,4-naftohinon:oksidovani-ditiotreitol oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 2-metil-3-fitil-1,4-naftohinon + oksidovani ditiotreitol 2,3-epoksi-2,3-dihidro-2-metil-3-fitil-1,4-naftohinon + 1,4-ditiotreitol
U reverznoj reakciji se vitamin K 2,3-epoksid redukuje do vitamina K, a potencijalno i do vitamin K hidrohinona posrestvom 1,4-ditiotreitola, koji se oksiduje do disulfida.
Reference[uredi | uredi kod]
- ↑ Lee, J.L. and Fasco, M.J. (1984). „Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide”. Biochemistry 23: 2246-2252. PMID 6733086.
- ↑ Mukharji, I. and Silverman, R.B. (1985). „Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone”. Proc. Natl. Acad. Sci. USA 82: 2713-2717. PMID 3857611.
- ↑ Whitlon, D.S., Sadowski, J.A. and Suttie, J.W. (1978). „Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition”. Biochemistry 17: 1371-1377. PMID 646989.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.