Ubikvitinilna hidrolaza 1
| Ubikvitinilna hidrolaza 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.12 | ||||||||
| CAS broj | 86480-67-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ubikvitinilna hidrolaza 1 (EC 3.4.19.12, ubikvitin C-terminalna hidrolaza, kvaščana ubikvitinska hidrolaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- TioL-zavisna hidroliza estarskih, tioestarskih, amidnih, peptidnih i izopeptidnih veza formiranih preko C-terminalnog Gly ubikvitina
Ovaj enzim brže razlaže polipeptide sa manje od 60 ostataka.
- ↑ Johnston, S.C., Larsen, C.N., Cook, W.J., Wilkinson, K.D. and Hill, C.P. (1997). „Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8Å resolution”. EMBO J. 16: 3787-3796. PMID 9233788.
- ↑ Wilkinson, K.D. (1998). „Ubiquitin C-terminal hydrolase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 470-472.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Wilkinson, K.D. (1998). „Ubiquitin C-terminal hydrolase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 470-472.