TRNKIle-lizidinska sintaza
(Preusmjereno sa stranice TRNAIle-lysidine synthetase)
| TRNKIle-lizidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.4.19 | ||||||||
| CAS broj | 635304-92-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNKIle-lizidinska sintaza (EC 6.3.4.19, TilS, mesJ (gen), yacA (gen), izoleucin-specifični transfer ribonukleat lizidinska sintetaza, tRNKIle-lizidinska sintetaza) je enzim sa sistematskim imenom L-lizin:(tRNKIle2)-citidin34 ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Bakterijski enzim modifikuje nestabilnu bazu CAU antikodona u tRNKIle molekulu.
Reference[uredi | uredi kod]
- ↑ Ikeuchi, Y., Soma, A., Ote, T., Kato, J., Sekine, Y. and Suzuki, T. (2005). „molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition”. Mol. Cell 19: 235-246. PMID 16039592.
- ↑ Salowe, S.P., Wiltsie, J., Hawkins, J.C. and Sonatore, L.M. (2009). „The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase”. J. Biol. Chem. 284: 9656-9662. PMID 19233850.
- ↑ Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T. and Nureki, O. (2005). „Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain”. Proc. Natl. Acad. Sci. USA 102: 7487-7492. PMID 15894617.
- ↑ Soma, A., Ikeuchi, Y., Kanemasa, S., Kobayashi, K., Ogasawara, N., Ote, T., Kato, J., Watanabe, K., Sekine, Y. and Suzuki, T. (2003). „An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA”. Mol. Cell 12: 689-698. PMID 14527414.
- ↑ Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R. and Nureki, O. (2009). „Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase”. Nature 461: 1144-1148. PMID 19847269.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.