Sfingomijelinska fosfodiestaraza
| Sfingomijelinska fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.4.12 | ||||||||
| CAS broj | 9031-54-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sfingomijelinska fosfodiestaraza (EC 3.1.4.12, neutralna sfingomijelinaza) je enzim sa sistematskim imenom sfingomielin holinfosfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sfingomijelin + H2O keramid + fosfoholin
Ovaj enzim ima neznatnu aktivnost na fosfatidilholinu.
- ↑ Barnholz, Y., Roitman, A. and Gatt, S. (1966). „Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain”. J. Biol. Chem. 241: 3731-3737. PMID 5916388.
- ↑ Chatterjee, S. and Ghosh, N. (1989). „Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies”. J. Biol. Chem. 264: 12554-12561. PMID 2545711.
- ↑ Heller, M. and Shapiro, B. (1966). „Enzymic hydrolysis of sphingomyelin by rat liver”. Biochem. J. 98: 763-769. PMID 5911524.
- ↑ Kanfer, J.N., Young, O.M., Shapiro, D. and Brady, R.O. (1966). „The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue”. J. Biol. Chem. 241: 1081-1084. PMID 5933867.
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