Sfingomijelin sintaza
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| Sfingomijelin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.27 | ||||||||
| CAS broj | 58703-97-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sfingomijelin sintaza (EC 2.7.8.27, SM sintaza, SMS1, SMS2) je enzim sa sistematskim imenom keramid:fosfatidilholin holinfosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- keramid + fosfatidilholin sfingomijelin + 1,2-diacil-sn-glicerol
Ova reakcija može da teče u oba smera.
Reference[uredi | uredi kod]
- ↑ Ullman, M.D. and Radin, N.S. (1974). „The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver”. J. Biol. Chem. 249: 1506-1512. PMID 4817756.
- ↑ Voelker, D.R. and Kennedy, E.P. (1982). „Cellular and enzymic synthesis of sphingomyelin”. Biochemistry 21: 2753-2759. PMID 7093220.
- ↑ Huitema, K., van den Dikkenberg, J., Brouwers, J.F. and Holthuis, J.C. (2004). „Identification of a family of animal sphingomyelin synthases”. EMBO J. 23: 33-44. PMID 14685263.
- ↑ Tafesse, F.G., Ternes, P. and Holthuis, J.C. (2006). „The multigenic sphingomyelin synthase family”. J. Biol. Chem. 281: 29421-29425. PMID 16905542.
- ↑ Yamaoka, S., Miyaji, M., Kitano, T., Umehara, H. and Okazaki, T. (2004). „Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells”. J. Biol. Chem. 279: 18688-18693. PMID 14976195.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.