Sfingomijelinska fosfodiestaraza D
(Preusmjereno sa stranice Sfingomijelin fosfodiestaraza D)
| Sfingomijelinska fosfodiestaraza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.41 | ||||||||
| CAS broj | 54992-31-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sfingomijelinska fosfodiestaraza D (EC 3.1.4.41, sfingomijelinaza D) je enzim sa sistematskim imenom sphingomijelin keramid-fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sfingomijelin + H2O keramid fosfat + holin
Ovaj enzim ne deluje na fosfatidilholin, ali hidrolizuje 2-lizofosfatidilholin do holina i 2-lizofosfatidata.
Reference[uredi | uredi kod]
- ↑ Carne, H.R. and Onon, E. (1978). „Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels”. Nature 271: 246-248. PMID 622164.
- ↑ Soucek, A., Michalec, C. and Souckov, A. (1971). „Identification and characterization of a new enzyme of the group phospholipase D isolated from Corynebacterium ovis”. Biochim. Biophys. Acta 227: 116-128. PMID 5543581.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.