Saharopin dehidrogenaza (NAD+, formira L-glutamat)
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| Saharopin dehidrogenaza (NAD+, formira L-glutamat) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.9 | ||||||||
| CAS broj | 37256-26-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Saharopin dehidrogenaza (NAD+, formira L-glutamat) (EC 1.5.1.9, dehidrogenaza, saharopin (formira nikotinamid adenin dinukleotid, glutamat), saharopinska dehidrogenaza, NAD+ oksidoreduktaza (formira L-2-aminoadipic-delta-semialdehid i glutamat), aminoadipinski semialdehid sintaza, 6-N-(L-1,3-dikarboksipropil)-L-lizin:NAD+ oksidoreduktaza (formira L-glutamat)) je enzim sa sistematskim imenom N6-(L-1,3-dikarboksipropil)-L-lizin:NAD+ oksidoreduktaza (formira L-glutamat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N6-(L-1,3-dikarboksipropil)-L-lizin + NAD+ +H2O L-glutamat + (S)-2-amino-6-oksoheksanoat + NADH + H+
Ovaj enzim se javlja zajedno sa EC 1.5.1.8, saharopinskom dehidrogenazom (NADP+, formira L-lizin).
Reference[uredi | uredi kod]
- ↑ Hutzler, J. and Dancis, J. (1968). „Conversion of lysine to saccharopine by human tissues”. Biochim. Biophys. Acta 158: 62-69. PMID 4385118.
- ↑ Markovitz, P.J., Chuang, D.T. and Cox, R.P. (1984). „Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities”. J. Biol. Chem. 259: 11643-11646. PMID 6434529.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.