Pseudolizin
(Preusmjereno sa stranice Pseudomonas elastaza)
| Pseudolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.26 | ||||||||
| CAS broj | 171715-23-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pseudolizin (EC 3.4.24.26, Pseudomonas elastaza, Pseudomonas aeruginosa neutralna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina uključujući elastin, kolagen tipa III i IV, fibronektin i imunoglobulin A, generalno sa glomaznim hidrofobnim grupama u P1'. Lanac insulina B se razlaže na identičnom šablonu prepoznavanja sa termolizinom, ali postoje razlike u specifinosti u drugim pogledima
Ovaj enzim pripada peptidaznoj familiji M4 (termolizinskoj familiji).
Reference[uredi | uredi kod]
- ↑ Morihara, K. and Tsuzuki, H. (1975). „Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase”. Agric. Biol. Chem. 39: 1123-1128.
- ↑ Nishino, N. and Powers, J.C. (1980). „Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand”. J. Biol. Chem. 255: 3482-3486. PMID 6767718.
- ↑ Dreyfus, L.A. and Iglewski, B.H. (1986). „Purification and characterization of an extracellular protease of Legionella pneumophila”. Infect. Immun. 70: 736-743. PMID 3512431.
- ↑ Bever, R.A. and Iglewski, B.H. (1988). „Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene”. J. Bacteriol. 170: 4309-4314. PMID 2842313.
- ↑ Black, W.J., Quinn, F.D. and Tompkins, L.S. (1990). „Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase”. J. Bacteriol. 172: 2608-2613. PMID 2110146.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.