Pseudolizin

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Pseudolizin
Identifikatori
EC broj 3.4.24.26
CAS broj 171715-23-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pseudolizin (EC 3.4.24.26, Pseudomonas elastaza, Pseudomonas aeruginosa neutralna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina uključujući elastin, kolagen tipa III i IV, fibronektin i imunoglobulin A, generalno sa glomaznim hidrofobnim grupama u P1'. Lanac insulina B se razlaže na identičnom šablonu prepoznavanja sa termolizinom, ali postoje razlike u specifinosti u drugim pogledima

Ovaj enzim pripada peptidaznoj familiji M4 (termolizinskoj familiji).

Reference[uredi - уреди | uredi izvor]

  1. Morihara, K. and Tsuzuki, H. (1975). "Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase". Agric. Biol. Chem. 39: 1123–1128. 
  2. Nishino, N. and Powers, J.C. (1980). "Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand". J. Biol. Chem. 255: 3482–3486. PMID 6767718. 
  3. Dreyfus, L.A. and Iglewski, B.H. (1986). "Purification and characterization of an extracellular protease of Legionella pneumophila". Infect. Immun. 70: 736–743. PMID 3512431. 
  4. Bever, R.A. and Iglewski, B.H. (1988). "Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene". J. Bacteriol. 170: 4309–4314. PMID 2842313. 
  5. Black, W.J., Quinn, F.D. and Tompkins, L.S. (1990). "Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase". J. Bacteriol. 172: 2608–2613. PMID 2110146. 

Literatura[uredi - уреди | uredi izvor]

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