Prolin dehidrogenaza
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| Prolin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Prolin dehidrogenaza tetramer, Bradyrhizobium diazoefficiens | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.5.99.8 | ||||||||
| CAS broj | 9050-70-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Prolin dehidrogenaza (EC 1.5.99.8, L-prolinska dehidrogenaza, L-prolin:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom L-prolin:akceptor oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-prolin + akceptor (S)-1-pirolidin-5-karboksilat + redukovani akceptor
Ovaj enzim je flavoprotein (FAD). U mnogim organizmima, od bakterija do sisara, prolin se oksiduje do glutamata u dvostepenom procesu koji obuhvata ovaj enzim i EC 1.5.1.12, 1-pirolidin-5-karboksilat dehidrogenazu.
Reference[uredi | uredi kod]
- ↑ Scarpulla, R.C. and Sofer, R.L. (1978). „Membrane-bound proline dehydrogenase from Escherichia coli. Solubilization, purification, and characterization”. J. Biol. Chem. 253: 5997-6001. PMID 355248.
- ↑ Forlani, G., Scainelli, D. and Nielsen, E. (1997). „Δ1-Pyrroline-5-carboxylate dehydrogenase from cultured cells of potato (purification and properties)”. Plant Physiol. 113: 1413-1418. PMID 12223682.
- ↑ Brown, E.D. and Wood, J.M. (1992). „Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli”. J. Biol. Chem. 267: 13086-13092. PMID 1618807.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.