Pirolin-5-karboksilat reduktaza
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| Dekamer pirolin-5-karboksilat reduktaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.5.1.2 | ||||||||
| CAS broj | 9029-17-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Pirolin-5-karboksilat reduktaza (EC 1.5.1.2, prolinska oksidaza, L-prolinska oksidaza, 1-pirolidin-5-karboksilat reduktaza, NADPH-L-Delta1-pirolidin karboksilna kiselina reduktaza, L-prolin-NAD(P)+ 5-oksidoreduktaza) je enzim sa sistematskim imenom L-prolin:NAD(P)+ 5-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-prolin + NAD(P)+ 1-pirolidin-5-karboksilat + NAD(P)H + H+
Ovaj enzim takođe redukuje 1-pirolidin-3-hidroksi-5-karboksilat do L-hidroksiprolina.
Reference[uredi | uredi kod]
- ↑ Adams, E. and Goldstone, A. (1960). „Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Δ1-pyrroline-3-hydroxy-5-carboxylate”. J. Biol. Chem. 235: 3499-3503. PMID 13681369.
- ↑ Meister, A., Radhakrishnan, A.N. and Buckley, S.D. (1957). „Enzymatic synthesis of L-pipecolic acid and L-proline”. J. Biol. Chem. 229: 789-800. PMID 13502341.
- ↑ Smith, M.E. and Greenberg, D.M. (1956). „Characterization of an enzyme reducing pyrroline-5-carboxylate to proline”. Nature (Lond.) 177: 1130-1130. PMID 13334497.
- ↑ Yura, T. and Vogel, H.J. (1959). „Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties”. J. Biol. Chem. 234: 335-338. PMID 13630905.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.