L-lizin 6-monooksigenaza (NADPH)
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L-lizin 6-monooksigenaza (NADPH) | |||||||||
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Identifikatori | |||||||||
EC broj | 1.14.13.59 | ||||||||
CAS broj | 64295-82-5 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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L-lizin 6-monooksigenaza (NADPH) (EC 1.14.13.59, lizinska N6-hidroksilaza, L-lizinska 6-monooksigenaza (NADPH) (nespecifična)) je enzim sa sistematskim imenom L-lizin,NADPH:kiseonik oksidoreduktaza (6-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-lizin + NADPH + H+ + O2 N6-hidroksi-L-lizin + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD). Enzim iz EN 222 vrste Escherichia coli je visoko specifičan za L-lizin. L-ornitin i L-homolizin nisu supstrati.
Reference[uredi | uredi kod]
- ↑ Plattner, H.J., Pfefferle, P., Romaguera, A., Waschutza, S. and Diekmann, H. (1989). „Isolation and some properties of lysine N6-hydroxylase from Escherichia coli strain EN222”. Biol. Met. 2: 1-5. PMID 2518519.
- ↑ Macheroux, P., Plattner, H.J., Romaguera, A. and Diekmann, H. (1993). „FAD and substrate analogs as probes for lysine N6-hydroxylase from Escherichia coli EN 222”. Eur. J. Biochem. 213: 995-1002. PMID 8504838.
- ↑ Thariath, A.M., Fatum, K.L., Valvano, M.A. and Viswanatha, T. (1993). „Physico-chemical characterization of a recombinant cytoplasmic form of lysine: N6-hydroxylase”. Biochim. Biophys. Acta 1203: 27-35. PMID 8218389.
- ↑ de Lorenzo, V., Bindereif, A., Paw, B.H. and Neilands, J.B. (1986). „Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12”. J. Bacteriol. 165: 570-578. PMID 2935523.
- ↑ Marrone, L., Siemann, S., Beecroft, M. and Viswanatha, T. (1996). „Specificity of lysine:N-6-hydroxylase: A hypothesis for a reactive substrate intermediate in the catalytic mechanism”. Bioorg. Chem. 24: 401-406.
- ↑ Goh, C.J., Szczepan, E.W., Menhart, N. and Viswanatha, T. (1989). „Studies on lysine: N6-hydroxylation by cell-free system of Aerobacter aerogenes 62-1”. Biochim. Biophys. Acta 990: 240-245. PMID 2493814.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.