Glutation transferaza
| Glutation transferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.5.1.18 | ||||||||
| CAS broj | 50812-37-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutation transferaza (EC 2.5.1.18, glutation S-transferaza, glutation S-alkiltransferaza, glutation S-ariltransferaza, S-(hidroksialkil)glutation lijaza, glutation S-aralkiltransferaza, glutation S-alkil transferaza, GST) je enzim sa sistematskim imenom RX:glutation R-transferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- RX + glutation HX + R-S-glutation
Ova grupa enzima ima široku specifičnost. R može da bude alifatična, aromatična ili heterociklična grupa; X može da bude sulfatna, nitrilna ili halidna grupa.
- ↑ Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974). „Glutathione S-transferases. The first enzymatic step in mercapturic acid formation”. J. Biol. Chem. 249: 7130-7139. PMID 4436300.
- ↑ Jakoby, W.B. (1978). „The glutathione S-transferases: a group of multifunctional detoxification proteins”. Adv. Enzymol. Relat. Areas Mol. Biol. 46: 383-383. PMID 345769.
- ↑ Jakoby, W.B. (1985). „Glutathione transferases: an overview”. Methods Enzymol. 113: 495-499. PMID 4088070.
- ↑ Keen, J.H. and Jakoby, W.B. (1978). „Glutathione transferases. Catalysis of nucleophilic reactions of glutathione”. J. Biol. Chem. 253: 5654-5657. PMID 670218.
- ↑ Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A. (2001). „Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily”. Biochem. J. 360: 1-16. PMID 11695986.
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