Gentamicin 2"-nukleotidiltransferaza
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| Gentamicin 2"-nukleotidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.46 | ||||||||
| CAS broj | 62213-33-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gentamicin 2"-nukleotidiltransferaza (EC 2.7.7.46, gentamicin 2-adenililtransferaza, aminoglikozidna adenililtransferaza, gentamicinska 2-nukleotidiltransferaza) je enzim sa sistematskim imenom NTP:gentamicin 2-nukleotidiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nukleozid trifosfat + gentamicin difosfat + 2-nukleotidilgentamicin
ATP, dATP, CTP, ITP i GTP mogu da deluju kao donori; kanamicin, tobramicin i sizomicin takođe deluju kao akceptori.
Reference[uredi | uredi kod]
- ↑ Angelatou, F., Litsas, S.B. and Kontomichalou, P. (1982). „Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa”. J. Antibiot. 35: 235-244. PMID 6281224.
- ↑ Naganawa, H., Yagisawa, M., Kondo, S., Takeuchi, T. and Umezawa, H. (1971). „The structure determination of an enzymatic inactivation product of 3′,4′-dideoxykanamycin B”. J. Antibiot. 24: 913-914. PMID 4946513.
- ↑ Yagisawa, M., Naganawa, H., Kondo, S., Hamada, M., Takeuchi, T. and Umezawa, H. (1971). „Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor”. J. Antibiot. 24: 911-912. PMID 4946512.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.