Daktilizin
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| Daktilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.60 | ||||||||
| CAS broj | 139466-40-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Daktilizin (EC 3.4.24.60, endopeptidaza inaktivacije peptidnog hormona, PHIE) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza peptida sa najmanje šest ostataka, sa glomaznim hidrofobnim ostacima u P1' poziciji. Ispoljava preferenciju za hidrofobne doublete kao što su -Phe-Phe- i -Phe-Leu- u somatostatin-(1-14)-peptidu i dinorfin A-(1-6)-peptidu, respektivno
Ova endopeptidaza se izlučuje iz kože vodozemca Xenopus laevis.
Reference[uredi | uredi kod]
- ↑ Carvalho, K.M., Joudiou, C., Boussetta, H., Leseney, A.-M. and Cohen, P. (1992). „A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion”. Proc. Natl. Acad. Sci. USA 89: 84-88. PMID 1729723.
- ↑ Delporte, C., Carvalho, K.M., Leseney, A.-M., Winand, J., Christophe, J. and Cohen, P. (1992). „A new metallo-endopeptidase from human neuroblastoma NB-OK-1 cells which inactivates atrial natriuretic peptide by selective cleavage at the Ser123-Phe124 bond”. Biochem. Biophys. Res. Commun. 182: 158-164. PMID 1531011.
- ↑ Joudiou, C., Carvalho, K.M., Camarao, G., Boussetta, H. and Cohen, P. (1993). „Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone inactivating enzyme”. Biochemistry 32: 5959-5966. PMID 8507636.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.