D-prolin reduktaza (ditiol)
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| D-prolin reduktaza (ditiol) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.4.1 | ||||||||
| CAS broj | 37255-43-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-prolin reduktaza (ditiol) (EC 1.21.4.1, D-proline reductase (dithiol)) je enzim sa sistematskim imenom 5-aminopentanoat:lipoat oksidoreduktaza (ciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-aminopentanoat + lipoat D-prolin + dihidrolipoat
Reakcija se odviaj u smeru redukcije D-prolina. Drugi ditioli mogu da deluju kao redukujući agensi.
Reference[uredi | uredi kod]
- ↑ Hodgins, D.S. and Abeles, R.H. (1969). „Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process”. Arch. Biochem. Biophys. 130: 274-285. PMID 5778643.
- ↑ Stadtman, T.C. and Elliott, P. (1957). „Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii”. J. Biol. Chem. 228: 983-997. PMID 13475375.
- ↑ Kabisch, U.C., Gräntzdörffer, A., Schierhorn, A., Rücknagel, K.P, Andreesen, J.R. and Pich, A. (1999). „Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein”. J. Biol. Chem. 274: 8445-8454. PMID 10085076.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.