Aminopeptidaza Y
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| Aminopeptidaza Y | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Lizilna aminopeptidaza dodekamer, Pyrococcus furiosus | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.11.15 | ||||||||
| CAS broj | 114796-97-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aminopeptidaza Y (EC 3.4.11.15, aminopeptidaza Co, aminopeptidaza (kobaltom aktivirana), lizilna aminopeptidaza) je enzim'.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno odvajanje N-terminalnog lizina
Za dejstvo ovog enzima je neophodan Co2+. Inhibiraju ga Zn2+ i Mn2+.
Reference[uredi | uredi kod]
- ↑ Achstetter, T., Ehmann, C. and Wolf, D.H. (1982). „Aminopeptidase Co, a new yeast peptidase”. Biochem. Biophys. Res. Commun. 109: 341-347. PMID 6758786.
- ↑ Yasuhara, T., Nakai, T. and Ohashi, A. (1994). „Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B”. J. Biol. Chem. 269: 13644-13650. PMID 8175799.
- ↑ Nishizawa, M., Yasuhara, T., Nakai, T., Fujiki, Y. and Ohashi, A. (1994). „Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase”. J. Biol. Chem. 269: 13651-13655. PMID 8175800.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.