Aminoglikozid N3'-acetiltransferaza
| Aminoglikozid N3'-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.81 | ||||||||
| CAS broj | 60120-42-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminoglikozid N3'-acetiltransferaza (EC 2.3.1.81, 3'-aminoglikozidna acetiltransferaza, 3-N-aminoglikozidna acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:2-dezoksistreptamin-antibiotik N3'-acetiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + 2-dezoksistreptamin antibiotik KoA + N3'-acetil-2-dezoksistreptamin antibiotik
Ovaj enzim se razlikuje od enzima EC 2.3.1.60, gentamicin 3'-N-acetiltransferaze. Širok opseg antibiotika koji sadrže 2-dezoksistreptaminski prsten mogu deluju kao akceptori, uključujući gentamicin, kanamicin, tobramicin, neomicin and apramicin.
- ↑ Davies, J. and O'Connor, S. (1978). „Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin”. Antimicrob. Agents Chemother. 14: 69-72. PMID 356726.
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