3a,7a-dihidroksi-5b-holestanat-KoA ligaza
| 3a,7a-dihidroksi-5b-holestanat-KoA ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.2.1.28 | ||||||||
| CAS broj | 118732-03-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3a,7a-dihidroksi-5b-holestanat-KoA ligaza (EC 6.2.1.28, 3alfa,7alfa-dihidroksi-5beta-holestanoil koenzim A sintetaza, DHCA-KoA ligaza, 3alfa,7alfa-dihidroksi-5beta-holestanat:KoA ligaza (formira AMP)) je enzim sa sistematskim imenom (25R)-3alfa,7alfa-dihidroksi-5beta-holestan-26-oat:KoA ligaza (formira AMP).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + (25R)-3alfa,7alfa-dihidroksi-5beta-holestan-26-oat + KoA AMP + difosfat + (25R)-3alfa,7alfa-dihidroksi-5beta-holestanoil-KoA
- ↑ Prydz, K., Kase, B.F., Björkhem, I. and Pedersen, J.I. (1988). „Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver”. J. Lipid Res. 29: 997-1004. PMID 3183523.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.