Temazepam
Prijeđi na navigaciju
Prijeđi na pretragu
| |||
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 7-hloro-1,3-dihidro-3-hidroksi-1-metil-5-fenil-1,4-benzodiazepin-2-on | |||
| Klinički podaci | |||
| Robne marke | Restoril | ||
| AHFS/Drugs.com | Monografija | ||
| MedlinePlus | a684003 | ||
| Identifikatori | |||
| CAS broj | 846-50-4 | ||
| ATC kod | N05CD07 | ||
| PubChem[1][2] | 5391 | ||
| DrugBank | DB00231 | ||
| ChemSpider[3] | 5198 | ||
| UNII | CHB1QD2QSS 
| ||
| KEGG[4] | D00370
| ||
| ChEMBL[5] | CHEMBL967
| ||
| Hemijski podaci | |||
| Formula | C16H13ClN2O2 | ||
| Mol. masa | 300,7 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakokinetički podaci | |||
| Bioraspoloživost | 96% | ||
| Metabolizam | Hepatički | ||
| Poluvreme eliminacije | 8–20 sata | ||
| Izlučivanje | Renalno | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | C(AU) X(US) | ||
| Pravni status | Samo na recept (S4) (AU) Schedule IV (CA) POM (UK) Schedule IV (SAD) | ||
| Način primene | Oralno | ||
Temazepam (Restoril - 15 mg/30 mg i Normison) hipnotik je srednje brzine dejstva. On je 3-hidroksi derivat iz benzodiazepinske klase psihoaktivnih lekova. Temazepam je odobren za kratkotrajne tretmane insomnije. Pored toga, temazepam ima anksiolitička, antikonvulsivna, i miorelaksantna svojstva.[6][7][8]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Wynn RL; McFarland SA, Meyer EA, Coffman WB, Mumford R (1980). „Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics”. Pharmacol Ther Dent 5 (1-2): 39–45. PMID 6774348.
- ↑ Siciliani O; Schiavon M, Tansella M (August 1975). „Anxiety and EEG alpha activity in neurotic patients”. Acta Psychiatr Scand 52 (2): 116–31. DOI:10.1111/j.1600-0447.1975.tb00028.x. PMID 1096540.
- ↑ Fuccella LM (1979). „Bioavailability of temazepam in soft gelatin capsules” (PDF). Br J Clin Pharmacol 8 (1): 31S–5S. PMC 1429631. PMID 41540.
