BML-190

BML-190
(IUPAC) ime
	2-[1-(4-hlorobenzoil)-5-metoksi-2-metilindol-3-il]-1-morfolin-4-iletanon
Klinički podaci
Identifikatori
CAS broj	2854-32-2
ATC kod	nije dodeljen
PubChem	2415
ChemSpider	2321
Hemijski podaci
Formula	C23H23ClN2O4
Mol. masa	426,892
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3 ; Key: BJSDNVVWJYDOLK-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

BML-190 (Indometacin morfolinilamid) je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivan inverzni agonist CB₂ receptora.^[4] BML-190 je strukturni analog NSAID indometacina koji ima sasvim različita biološka svojstava.^[5] Neki izvori osporavaju aktivnost ovoj jedinjenja, i navode da je CB₂ agonist umesto inverznog agonista.^[6]^[7] Razlog za to može da bude greška u klasifikaciji, ili alternativno moguće je da ovaj materijal proizvodi različite efekte u različitim tkivima i eksperimentalnim uslovima.

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ New, DC; Wong, YH (2003). „BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates”. FEBS Letters 536 (1–3): 157–60. DOI:10.1016/S0014-5793(03)00048-6. PMID 12586356.
↑ Klegeris, A; Bissonnette, CJ; McGeer, PL (2003). „Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor”. British Journal of Pharmacology 139 (4): 775–86. DOI:10.1038/sj.bjp.0705304. PMC 1573900. PMID 12813001.
↑ Melck, D; De Petrocellis, L; Orlando, P; Bisogno, T; Laezza, C; Bifulco, M; Di Marzo, V (2000). „Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation”. Endocrinology 141 (1): 118–26. DOI:10.1210/en.141.1.118. PMID 10614630.
↑ Scutt, A; Williamson, EM (2007). „Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors”. Calcified tissue international 80 (1): 50–9. DOI:10.1007/s00223-006-0171-7. PMID 17205329.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] New, DC; Wong, YH (2003). „BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates”. FEBS Letters 536 (1–3): 157–60. DOI:10.1016/S0014-5793(03)00048-6. PMID 12586356.

[5] Klegeris, A; Bissonnette, CJ; McGeer, PL (2003). „Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor”. British Journal of Pharmacology 139 (4): 775–86. DOI:10.1038/sj.bjp.0705304. PMC 1573900. PMID 12813001.

[6] Melck, D; De Petrocellis, L; Orlando, P; Bisogno, T; Laezza, C; Bifulco, M; Di Marzo, V (2000). „Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation”. Endocrinology 141 (1): 118–26. DOI:10.1210/en.141.1.118. PMID 10614630.

[7] Scutt, A; Williamson, EM (2007). „Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors”. Calcified tissue international 80 (1): 50–9. DOI:10.1007/s00223-006-0171-7. PMID 17205329.

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BML-190

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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