AM-2389

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AM-2389
(IUPAC) ime
(6aR,9R,10aR)-3-(1-heksil-ciklobut-1-il)-6a,7,8,9,10,10a-heksahidro-6,6-dimetil-6H-dibenzo[b,d]piran-1,9 diol
Klinički podaci
Identifikatori
CAS broj 1256842-49-5
ATC kod ?
PubChem[1][2] 49783410
ChemSpider[3] 26333264
Hemijski podaci
Formula C25H38O3 
Mol. masa 386,566 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

AM-2389 je klasični kanabinoidni derivat koji deluje kao potentan i relativno selektivan agonist za CB1 receptora, sa Ki od 0,16 nM, i 26x selektivnošću u odnosu na srodni CB2 receptor. On ima visoku potentnost na životinjskim testovima kanabinoidne aktivnosti, i umerenu dužinu trajanja.[4][5].

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Nikas SP, et al. Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. Journal of Medicinal Chemistry. 2010 Oct 14;53(19):6996-7010. PMID 20925434
  5. Järbe TU, et al. AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice. Psychopharmacology (Berlin). 2011 Oct 12. PMID 21989802

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Šablon:Kanabinoidi