Levonantradol
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| [(6S,6aR,9R,10aR)- 9-hidroksi- 6-metil- 3-[(2R)-5-fenilpentan- 2-il]oksi- 5,6,6a,7,8,9,10,10a-oktahidrofenantridin- 1-il] acetat | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 71048-87-8 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 5361881 | ||
| ChemSpider[3] | 4514867 | ||
| UNII | 03S640ADSK 
| ||
| Hemijski podaci | |||
| Formula | C27H35NO4 | ||
| Mol. masa | 437,571 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Levonantradol (CP 50,556-1) je sintetički kanabinoidni analog dronabinola (Marinola). Ovaj lek je razvila kompanija Pfizer tokom 1980-tih. On je oko 30x puta potentniji od THC, i manifestuje antiemetske i analgetske efekte putem aktivacije CB1 i CB2 kanabinoidnih receptora.[4] Levonantradol trenutno nije u upotrebi jer su dronabinol i nabilon primenljivi na veći broj oboljenja. On nalazi široku primenu u istraživanju potencijalne terapeutske primene kanabinoida.[5][6][7]
Vidi još[uredi | uredi kod]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Little PJ, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.
- ↑ Tramer MR, et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. British Medical Journal 2001 Jul 7;323(7303):16-21.
- ↑ Campbell FA, et al. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. British Medical Journal. 2001 Jul 7;323(7303):13-6.
- ↑ Ben Amar M. Cannabinoids in medicine: A review of their therapeutic potential. Journal of Ethnopharmacology. 2006 Apr 21;105(1-2):1-25.
Literatura[uredi | uredi kod]
- Childers, SR (2006-03-10). „Activation of G-proteins in brain by endogenous and exogenous cannabinoids.”. The AAPS journal 8 (1): E112–7. DOI:10.1208/aapsj080113. PMC 2751429. PMID 16584117.
- Hosking, R.D.; Zajicek, J.P. (2008). „Therapeutic potential of cannabis in pain medicine”. British Journal of Anaesthesia 101 (1): 59–68.
- McCarthy, LE; Borison, HL (1981). „Antiemetic activity of N-methyllevonantradol and nabilone in cisplatin-treated cats.”. Journal of clinical pharmacology 21 (8–9 Suppl): 30S-37S. PMID 6271834.
- Milewich, L; Gant, NF; Schwarz, BE; Chen, GT; MacDonald, PC (1979-03-15). „5 alpha-Reductase activity in human placenta.”. American journal of obstetrics and gynecology 133 (6): 611–7. PMID 34324.
