Uroporfirinogen-III C-metiltransferaza
| Uroporfirinogen-III C-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.107 | ||||||||
| CAS broj | 125752-76-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Uroporfirinogen-III C-metiltransferaza (EC 2.1.1.107, uroporfirinogenska metiltransferaza, uroporfirinogen-III metiltransferaza, adenozilmetionin-uroporfirinogen III metiltransferaza, S-adenozil-L-metionin-zavisna uroporfirinogenska III metilaza, uroporfirinogen-III metilaza, SirA, CysG, CobA, SUMT, uroporfirin-III C-metiltransferaza, S-adenozil-L-metionin:uroporfirin-III C-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:uroporfirinogen-III C-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + uroporfirinogen III 2 S-adenozil-L-homocistein + prekorin-2 (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + uroporfirinogen III S-adenozil-L-homocistein + prekorin-1
- (1b) S-adenozil-L-metionin + prekorin-1 S-adenozil-L-homocistein + prekorin-2
Ovaj enzim katalizuje dve sekvencijalne reakcije metilacije. Prvom se formira prekorin-1, a druga dovodi do formiranja prekorina-2. To je prvi od tri koraka koji dovode do formiranja sirohema iz uroporfirinogena III.
Reference[uredi | uredi kod]
- ↑ Warren, M.J., Gonzalez, M.D., Williams, H.J., Stolowich, N.J. and Scott, A.I. (1990). „Uroporphyrinogen-III methylase catalyzes the enzymatic-synthesis of sirohydrochlorin-II and sirohydrochlorin-IV by a clockwise mechanism”. J. Am. Chem. Soc. 112: 5343-5345.
- ↑ Warren, M.J., Roessner, C.A., Santander, P.J. and Scott, A.I. (1990). „The Escherichia coli cysG gene encodes S-adenosylmethionine-dependent uroporphyrinogen III methylase”. Biochem. J. 265: 725-729. PMID 2407234.
- ↑ Schubert, H.L., Raux, E., Brindley, A.A., Leech, H.K., Wilson, K.S., Hill, C.P. and Warren, M.J. (2002). „The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase”. EMBO J. 21: 2068-2075. PMID 11980703.
Literatura[uredi | uredi kod]
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- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
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