UDP-N-acetilmuramat dehidrogenaza
| UDP-N-acetilmuramat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| UDP-N-acetilmuramat dehidrogenaza homodimer, Mycobacterium tuberculosis | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.1.98 | ||||||||
| CAS broj | 39307-28-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-N-acetilmuramat dehidrogenaza (EC 1.3.1.98, MurB reduktaza, UDP-N-acetilenolpiruvoilglukozaminska reduktaza, UDP-N-acetilglukozamin-enoilpiruvatna reduktaza, UDP-GlcNAc-enoilpiruvatna reduktaza, uridin difosfoacetilpiruvoilglukozaminska reduktaza, uridin difosfo-N-acetilglukozamin-enolpiruvatna reduktaza, uridin-5'-difosfo-N-acetil-2-amino-2-dezoksi-3-O-laktilglukoza:NADP-oksidoreduktaza) je enzim sa sistematskim imenom UDP-N-acetilmuramat:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetilmuramat + NADP+ UDP-N-acetil-3-O-(1-karboksivinil)-D-glukozamin + NADPH + H+
Dva supstrata UDP-N-acetilmuramatne dehidrogenaze su UDP-N-acetilmuramat i NADP+, doks su njena tri produkta: UDP-N-acetil-3-O-(1-karboksivinil)-D-glukozamin, NADPH, i H+.
Natrijum ditionit, natrijum borohidrid, i u manjoj meri, NADH, mogu da zamene NADPH.
Reference[uredi | uredi kod]
- ↑ Taku, A. and Anwar, R.A. (1973). „Biosynthesis of uridine diphospho-N-acetylmuramic acid. IV. Activation of uridine diphospho-N-acetylenolpyruvylglucosamine reductase by monovalent cations”. J. Biol. Chem. 248: 4971-1976. PMID 4717533.
- ↑ Taku, A., Gunetileke, K.G. and Anwar, R.A. (1970). „Biosynthesis of uridine diphospho-N-acetylmuramic acid. 3. Purification and properties of uridine diphospho-N-acetylenolpyruvyl-glucosamine reductase”. J. Biol. Chem. 245: 5012-5016. PMID 4394163.
- ↑ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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