Tropin dehidrogenaza
| Tropin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.206 | ||||||||
| CAS broj | 118390-87-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tropin dehidrogenaza (EC 1.1.1.206, tropinon reduktaza (ambiguous), TR-I) je enzim sa sistematskim imenom tropin:NADP+ 3alfa-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tropin + NADP+ tropinon + NADPH + H+
Tropinska dehidrogenaza takođe oksiduje druge tropan-3alfa-ole, ali ne i na korespondirajuće beta-derivate. Ovaj enzim zajedno sa EC 1.1.1.236, tropinonskom reduktazom II, predstavlja tačku grananja u tropanskom alkaloidnom metabolizmu. Tropin (produkt enzima EC 1.1.1.206 se inkorporira u hiosciamin i skopolamin, dok je pseudotropin (product enzima EC 1.1.1.236) prvi specifični metabolit na putu do kalistegina. Oba enzima su uvek zajedno prisutna u vrstama koji proizvode tropanski alkaloid. Oni imaju zajednički supstrat, tropinon, i striktno su stereospecifična.
- ↑ Koelen, K.J. and Gross, G.G. (1982). „Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium”. Planta Med. 44: 227-230.
- ↑ Couladis, M.M, Friesen, J.B., Landgrebe, M.E. and Leete, E. (1991). „Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia”. Pytochemistry 30: 801-805.
- ↑ Nakajima, K., Hashimoto, T. and Yamada, Y. (1993). „Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor”. Proc. Natl. Acad. Sci. USA 90: 9591-9595. PMID 8415746.
- ↑ Dräger, B. (2006). „Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism”. Phytochemistry 67: 327-337. PMID 16426652.
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