Triptofan 2,3-dioksigenaza

Triptofan 2,3-dioksigenaza
	Triptofan 2,3-dioksigenaza tetramer, Human
Identifikatori
EC broj	1.13.11.11
CAS broj	9014-51-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Triptofan 2,3-dioksigenaza (EC 1.13.11.11, triptofanska pirolaza (nespecifična), triptofanska oksigenaza, triptaminska 2,3-dioksigenaza, triptofanska peroksidaza, indolaminska 2,3-dioksigenaza (nespecifična), indolaminska 2,3-dioksigenaza (nespecifična), L-triptofan pirolaza, TDO, L-triptofanska 2,3-dioksigenaza) je enzim sa sistematskim imenom L-triptofan:kiseonik 2,3-oksidoreduktaza (deciklizacija).^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-triptofan + O₂

\rightleftharpoons

N-formil-L-kinurenin

Ovaj enzim je protohemoprotein. Kod sisara, enzim je lociran u jetri.

Reference[uredi - уреди | uredi izvor]

↑ Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iizuka, T., Ishimura, Y., Nozawa, T. and Hatano, M. (1983). "Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms". J. Biol. Chem. 258: 2519–2525. PMID 6600455.
↑ Ren, S., Liu, H., Licad, E. and Correia, M.A. (1996). "Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme". Arch. Biochem. Biophys. 333: 96–102. PMID 8806758.
↑ Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K. and Wiseman, J.S. (1993). "Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase". J. Biol. Chem. 268: 17781–17786. PMID 8349662.
↑ Dang, Y., Dale, W.E. and Brown, O.R. (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway". Free Radic. Biol. Med. 28: 615–624. PMID 10719243.
↑ Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). "Asp²⁷⁴ and His³⁴⁶ are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase". J. Biol. Chem. 278: 29525–29531. PMID 12766158.

Literatura[uredi - уреди | uredi izvor]

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.

Spoljašnje veze[uredi - уреди | uredi izvor]

MeSH Tryptophan+2,3-dioxygenase

[1] Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iizuka, T., Ishimura, Y., Nozawa, T. and Hatano, M. (1983). "Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms". J. Biol. Chem. 258: 2519–2525. PMID 6600455.

[2] Ren, S., Liu, H., Licad, E. and Correia, M.A. (1996). "Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme". Arch. Biochem. Biophys. 333: 96–102. PMID 8806758.

[3] Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K. and Wiseman, J.S. (1993). "Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase". J. Biol. Chem. 268: 17781–17786. PMID 8349662.

[4] Dang, Y., Dale, W.E. and Brown, O.R. (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway". Free Radic. Biol. Med. 28: 615–624. PMID 10719243.

[5] Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). "Asp²⁷⁴ and His³⁴⁶ are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase". J. Biol. Chem. 278: 29525–29531. PMID 12766158.

[1]

[2]

[3]

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[5]

Triptofan 2,3-dioksigenaza

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

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