Triptofan 2,3-dioksigenaza
| Triptofan 2,3-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Triptofan 2,3-dioksigenaza tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.13.11.11 | ||||||||
| CAS broj | 9014-51-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Triptofan 2,3-dioksigenaza (EC 1.13.11.11, triptofanska pirolaza (nespecifična), triptofanska oksigenaza, triptaminska 2,3-dioksigenaza, triptofanska peroksidaza, indolaminska 2,3-dioksigenaza (nespecifična), indolaminska 2,3-dioksigenaza (nespecifična), L-triptofan pirolaza, TDO, L-triptofanska 2,3-dioksigenaza) je enzim sa sistematskim imenom L-triptofan:kiseonik 2,3-oksidoreduktaza (deciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-triptofan + O2 N-formil-L-kinurenin
Ovaj enzim je protohemoprotein. Kod sisara, enzim je lociran u jetri.
- ↑ Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iizuka, T., Ishimura, Y., Nozawa, T. and Hatano, M. (1983). „Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms”. J. Biol. Chem. 258: 2519-2525. PMID 6600455.
- ↑ Ren, S., Liu, H., Licad, E. and Correia, M.A. (1996). „Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme”. Arch. Biochem. Biophys. 333: 96-102. PMID 8806758.
- ↑ Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K. and Wiseman, J.S. (1993). „Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase”. J. Biol. Chem. 268: 17781-17786. PMID 8349662.
- ↑ Dang, Y., Dale, W.E. and Brown, O.R. (2000). „Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway”. Free Radic. Biol. Med. 28: 615-624. PMID 10719243.
- ↑ Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). „Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase”. J. Biol. Chem. 278: 29525-29531. PMID 12766158.
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