Triptofan 2,3-dioksigenaza
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| Triptofan 2,3-dioksigenaza | |||||||||
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| Triptofan 2,3-dioksigenaza tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.13.11.11 | ||||||||
| CAS broj | 9014-51-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | structures | ||||||||
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Triptofan 2,3-dioksigenaza (EC 1.13.11.11, triptofanska pirolaza (nespecifična), triptofanska oksigenaza, triptaminska 2,3-dioksigenaza, triptofanska peroksidaza, indolaminska 2,3-dioksigenaza (nespecifična), indolaminska 2,3-dioksigenaza (nespecifična), L-triptofan pirolaza, TDO, L-triptofanska 2,3-dioksigenaza) je enzim sa sistematskim imenom L-triptofan:kiseonik 2,3-oksidoreduktaza (deciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-triptofan + O2 N-formil-L-kinurenin
Ovaj enzim je protohemoprotein. Kod sisara, enzim je lociran u jetri.
Reference[uredi - уреди | uredi izvor]
- ↑ Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iizuka, T., Ishimura, Y., Nozawa, T. and Hatano, M. (1983). "Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms". J. Biol. Chem. 258: 2519–2525. PMID 6600455.
- ↑ Ren, S., Liu, H., Licad, E. and Correia, M.A. (1996). "Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme". Arch. Biochem. Biophys. 333: 96–102. PMID 8806758.
- ↑ Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K. and Wiseman, J.S. (1993). "Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase". J. Biol. Chem. 268: 17781–17786. PMID 8349662.
- ↑ Dang, Y., Dale, W.E. and Brown, O.R. (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway". Free Radic. Biol. Med. 28: 615–624. PMID 10719243.
- ↑ Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). "Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase". J. Biol. Chem. 278: 29525–29531. PMID 12766158.
Literatura[uredi - уреди | uredi izvor]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.
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