Trans-akonitrat 2-metiltransferaza
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| Trans-akonitrat 2-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.144 | ||||||||
| CAS broj | 235107-12-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trans-akonitrat 2-metiltransferaza (EC 2.1.1.144) je enzim sa sistematskim imenom S-adenozil-L-metionin:(E)-prop-1-en-1,2,3-trikarboksilat 2'-O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + trans-akonitat S-adenozil-L-homocistein + (E)-3-(metoksikarbonil)pent-2-enedioat
Ovaj enzim takođe katalizuje formiranje metil monoestra cis-akonitata, izocitrata i citrata.
Reference[uredi | uredi kod]
- ↑ Cai, H. and Clarke, S. (1999). „A novel methyltransferase catalyzes the esterification of trans-aconitate in Escherichia coli”. J. Biol. Chem. 274: 13470-13479. PMID 10224113.
- ↑ Cai, H., Strouse, J., Dumlao, D., Jung, M.E. and Clarke, S. (2001). „Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferase”. Biochemistry 40: 2210-2219. PMID 11329290.
- ↑ Cai, H., Dumlao, D., Katz, J.E. and Clarke, S. (2001). „Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae”. Biochemistry 40: 13699-13709. PMID 11695919.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.