Toluen dioksigenaza
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| Toluen dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.11 | ||||||||
| CAS broj | 120038-36-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Toluen dioksigenaza (EC 1.14.12.11, toluenska 2,3-dioksigenaza) je enzim sa sistematskim imenom toluen,NADH:kiseonik oksidoreduktaza (1,2-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- toluen + NADH + H+ + O2 (1S,2R)-3-metilcikloheksa-3,5-dien-1,2-diol + NAD+
Ovaj enzim je gvožđe-sumporni flavoprotein (FAD).
Reference[uredi | uredi kod]
- ↑ Renganathan, V. (1989). „Possible involvement of toluene-2,3-dioxygenase in defluorination of 3-fluoro-substituted benzenes by toluene-degrading Pseudomonas sp. strain T-12”. Appl. Exp. Microbiol. 55: 330-334. PMID 16347845.
- ↑ Subramanian, V., Liu, T.-N., Yeh, W.K. and Gibson, D.T. (1979). „Toluene dioxygenase: purification of an iron-sulfur protein by affinity chromatography”. Biochem. Biophys. Res. Commun. 91: 1131-1139. PMID 526270.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.