Togavirin
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| Togavirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.90 | ||||||||
| CAS broj | 342882-56-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Togavirin (EC 3.4.21.90, Sindbis virus proteaza, Sindbis virus core protein, NsP2 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Autokatalitičko odvajanje sržnog proteina sa N-terminusa togavirusnog strukturnog poliproteina putem hidrolize -Trp-Ser- veze
Ovaj enzim kodiraju Sindbis i Semliki šumski togavirusi.
Reference[uredi | uredi kod]
- ↑ Kräusslich, H.-G. and Wimmer, E. (1988). „Viral proteinases”. Annu. Rev. Biochem. 57: 701-754. PMID 3052288.
- ↑ Strauss, E.G., De Groot, R.J., Levinson, R. and Strauss, J.H. (1992). „Identification of the active site residues in the nsP2 proteinase of Sindbis virus”. Virology 191: 932-940. PMID 1448929.
- ↑ Tong, L., Wengler, G. and Rossmann, M.G. (1993). „Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures”. J. Mol. Biol. 230: 228-247. PMID 8450538.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.