TRNK (guanin-N7-)-metiltransferaza
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| TRNK (guanin-N7-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.33 | ||||||||
| CAS broj | 37257-00-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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TRNK (guanin-N7-)-metiltransferaza (EC 2.1.1.33, Trm8/Trm82, TrmB, tRNK (m7G46) metiltransferaza, transfer ribonukleat guaninska 7-metiltransferaza, 7-metilguanin transfer ribonukleatna metilaza, tRNK guanin 7-metiltransferaza, N7-metilguaninska metilaza, S-adenozil-L-metionin:tRNK (guanin-7-N-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin-N7)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin46 u tRNK S-adenozil-L-homocistein + N7-metilguanin46 u tRNK
Ovaj enzim specifično metiliše guanin46 u poziciji N7 unutar tRNK.
Reference[uredi | uredi kod]
- ↑ Aschhoff, H.J., Elten, H., Arnold, H.H., Mahal, G., Kersten, W. and Kersten, H. (1976). „7-Methylguanine specific tRNA-methyltransferase from Escherichia coli”. Nucleic Acids Res. 3: 3109-3122. PMID 794833.
- ↑ Zegers, I., Gigot, D., van Vliet, F., Tricot, C., Aymerich, S., Bujnicki, J.M., Kosinski, J. and Droogmans, L. (2006). „Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase”. Nucleic Acids Res. 34: 1925-1934. PMID 16600901.
- ↑ Purta, E., van Vliet, F., Tricot, C., De Bie, L.G., Feder, M., Skowronek, K., Droogmans, L. and Bujnicki, J.M. (2005). „Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis”. Proteins 59: 482-488. PMID 15789416.
- ↑ Liu, Q., Gao, Y., Yang, W., Zhou, H., Gao, Y., Zhang, X., Teng, M. and Niu, L. (2008). „Crystallization and preliminary crystallographic analysis of tRNA (m7G46) methyltransferase from Escherichia coli”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 743-745. PMID 18678947.
- ↑ Alexandrov, A., Martzen, M.R. and Phizicky, E.M. (2002). „Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA”. RNA 8: 1253-1266. PMID 12403464.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.