T-Plasminogeni aktivator
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| T-Plasminogeni aktivator | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.4.21.68 | ||||||||
| CAS broj | 139639-23-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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T-Plasminogeni aktivator (EC 3.4.21.68, tkivni plazminogenski activator, plazminogenski aktivator, tkivni-tip, tkivni tip plazminogenskog aktivatora, tPA, t-PA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Specifično razlaganje Arg-Val veze u plazminogenu čime se formira plazmin
Ova peptidaza je prisutna u širokom opsegu tipova tkiva, a posebno u endotelnim ćelijama.
Reference[uredi | uredi kod]
- ↑ Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. (1983). „Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli”. Nature 301: 214-221. PMID 6337343.
- ↑ Loskutoff, D.J. and Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293-302. PMID 3148826.
- ↑ Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. (1988). „The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage”. Biochim. Biophys. Acta 952: 245-254. PMID 2962643.
- ↑ Verheijen, J.H. (1988). „Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma”. Methods Enzymol. 163: 302-309. PMID 3148827.
- ↑ Gerard, R.D. and Meidell, R.S. (1989). „Regulation of tissue plasminogen activator expression”. Annu. Rev. Physiol. 51: 245-262. PMID 2496643.
- ↑ Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.