Sulfiredoksin
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| Sulfiredoksin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.98.2 | ||||||||
| CAS broj | 710319-61-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | structures | ||||||||
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Sulfiredoksin (EC 1.8.98.2, Srx1, peroksiredoksin-(S-hidroksi-S-oksocistein) reduktaza) je enzim sa sistematskim imenom peroksiredoksin-(S-hidroksi-S-oksocistein):tiol oksidoreduktaza (ATP-hidroliza; formira peroksiredoksin-(S-hidroksicistein)).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- peroksiredoksin-(S-hidroksi-S-oksocistein) + ATP + 2 R-SH peroksiredoksin-(S-hidroksicistein) + ADP + fosfat + R-S-S-R
Tokom reakcije koju posreduje enzim EC 1.11.1.15, peroksiredoksin, njegov cisteinski ostatak se naizmenično oksiduje do sulfenske kiseline, S-hidroksicisteina, i redukuje nazad do cisteina. Povremeno se S-hidroksicisteinski ostatak dalje oksiduje do sulfinske kiseline, S-hidroksi-S-oksocisteina, čime se inaktivira enzim. Reduktaza pruža mehanizam za regeneraciju aktivne forme peroksiredoksina, i.e. peroksiredoksin-(S-hidroksicisteina).
Reference[uredi - уреди | uredi izvor]
- ↑ Biteau, B., Labarre, J. and Toledano, M.B. (2003). "ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin". Nature 425: 980–984. PMID 14586471.
- ↑ Chang, T.S., Jeong, W., Woo, H.A., Lee, S.M., Park, S. and Rhee, S.G. (2004). "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine". J. Biol. Chem. 279: 50994–51001. PMID 15448164.
- ↑ Woo, H.A., Jeong, W., Chang, T.S., Park, K.J., Park, S.J., Yang, J.S. and Rhee, S.G. (2005). "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-Cys peroxiredoxins". J. Biol. Chem. 280: 3125–3128. PMID 15590625.
Literatura[uredi - уреди | uredi izvor]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.
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