Striktozidinska sintaza
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| Striktozidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.3.2 | ||||||||
| CAS broj | 69669-72-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Striktozidinska sintaza (EC 4.3.3.2, striktozidinska sintetaza, STR, 3-alfa(S)-strijtozidin triptamin-lijaza) je enzim sa sistematskim imenom 3-alfa(S)-striktozidin triptamin-lijaza (formira sekologanin).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-alfa(S)-striktozidin + H2O triptamin + sekologanin
Ovaj enzim katalizuje Piktet-Spenglerovu reakciju između aldehidne grupe sekologanina i amino grupe of triptamina.
Reference[uredi | uredi kod]
- ↑ Treimer, J.K. and Zenk, M.H. (1979). „Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation”. Eur. J. Biochem. 101: 225-233. PMID 510306.
- ↑ Kutchan, T.M. (1993). „Strictosidine: from alkaloid to enzyme to gene”. Phytochemistry 32: 493-506. PMID 7763429.
- ↑ de Waal, A., Meijer, A.H. and Verpoorte, R. (1995). „Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms”. Biochem. J. 306: 571-580. PMID 7887913.
- ↑ Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. and Stöckigt, J. (2005). „Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system”. Planta 222: 888-898. PMID 16133216.
- ↑ McCoy, E., Galan, M.C. and O'Connor, S.E. (2006). „Substrate specificity of strictosidine synthase”. Bioorg. Med. Chem. Lett. 16: 2475-2478. PMID 16481164.
- ↑ Ma, X., Panjikar, S., Koepke, J., Loris, E. and Stöckigt, J. (2006). „The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed β-propeller fold in plant proteins”. Plant Cell 18: 907-920. PMID 16531499.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.