Selenat reduktaza
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| Selenat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.97.1.9 | ||||||||
| CAS broj | 146359-71-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Selenat reduktaza (EC 1.97.1.9, Selenate reductase) je enzim sa sistematskim imenom selenit:redukovani akceptor oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- selenit + H2O + akceptor selenat + redukovani akceptor
Periplazmički enzim iz Thauera selenatis je kompleks koji se sastoji od tri heterologne podjednice (alfa, beta i gama). On sadrži molibden, gvožđe, sulfid i hem B kao kofaktorske konstituente. Nitrat, nitrit, hlorat i sulfat su supstrati.
Reference[uredi | uredi kod]
- ↑ Schröder, I., Rech, S., Krafft, T. and Macy, J.M. (1997). „Purification and characterization of the selenate reductase from Thauera selenatis”. J. Biol. Chem. 272: 23765-23768. PMID 9295321.
- ↑ Macy, J.M., Rech, S., Auling, G., Dorsch, M., Stackebrandt, E. and Sly, L.I. (1993). „Thauera selenatis gen. nov., sp. nov., a member of the β subclass of Proteobacteria with a novel type of anaerobic respiration”. Int. J. Syst. Bacteriol. 43: 135-142. PMID 8427805.
- ↑ Krafft, T., Bowen, A., Theis, F. and Macy, J.M. (2000). „Cloning and sequencing of the genes encoding the periplasmic-cytochrome B-containing selenate reductase of Thauera selenatis”. DNA 10: 365-377. PMID 10826693.
- ↑ Stolz, J.F. and Oremland, R.S. (1999). „Bacterial respiration of arsenic and selenium”. FEMS Microbiol. Rev. 23: 615-627. PMID 10525169.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.